University of Twente Student Theses
An early Health Technology Assessment into the expected impacts and potential cost-effectiveness of the LoaD e-Health application to combat knee osteoarthritis
Rezai, M.S. (2024) An early Health Technology Assessment into the expected impacts and potential cost-effectiveness of the LoaD e-Health application to combat knee osteoarthritis.
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| Abstract: | Total knee replacement is the final treatment option for knee osteoarthritis patients. However, knee prosthetics have limited life spans and revision total knee replacements often have worse outcomes than primary total knee replacements. Therefore, an e-health application is being developed by the LoaD consortium that could slow down disease progression based on personalised movement advice. To inform its development, an early Health Technology Assessment is performed. The cost-effectiveness was explored by means of an individual level state transition model. Monte Carlo simulations and scenario analyses were performed to explore the impact of uncertainty of input parameters on the robustness of the ICER. Finally, a headroom analysis was performed to explore the maximum acceptable cost of the e-health application. Cost-savings ranged between €570 and €2494 per patient per year on average. Reducing the chance of disease progression and progression to surgery resulted in QALY losses ranging between -0.01 and -0.03. The reason for this was that pre-surgical utilities were lower. The maximum acceptable costs per patient per year ranged between €351 and €1998 at a WTP of €20000 per QALY. Ultimately, the application did not provide extra effect for additional costs, instead it provided cost-savings for similar health outcomes. |
| Item Type: | Essay (Master) |
| Faculty: | TNW: Science and Technology |
| Subject: | 44 medicine, 83 economics |
| Programme: | Health Sciences MSc (66851) |
| Link to this item: | https://purl.utwente.nl/essays/100604 |
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