University of Twente Student Theses
On-demand handling system for analysis and preparation of microsamples
Sikkema, H.G. (2024) On-demand handling system for analysis and preparation of microsamples.
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| Full Text Status: | Access to this publication is restricted |
| Embargo date: | 1 January 2025 |
| Abstract: | The dynamic behaviour of hormone concentrations is crucial to our everyday life. To better understand the effects of fluctuations in this behaviour, it should be measured and studied. Current state-of-the-art minimally invasive measurement techniques can sample hormones once every 10 minutes throughout a full day. However, studies that use more invasive techniques have shown that many hormones fluctuate at shorter time scales. This research aims to bridge the gap by designing a minimally invasive hormone-sampling system with a sample rate double that of the state-of-the-art. Two novel microfluidic systems have been designed using a combination of Quake valves and optical sensors: an active droplet generator with feedback and an active injector with feedback. Combining these two microfluidic systems results in an on-demand microsample handling system. It was designed to isolate the samples and prepare them for storage and further analysis. The valves and sensors that make up the system were designed, fabricated and validated. A setup was built to control the valves according to the sensors’ measurements. Using this setup, the active droplet generator with feedback was shown to work. Both concepts have promise, and whether they can live up to that could be examined in future research. |
| Item Type: | Essay (Master) |
| Faculty: | EEMCS: Electrical Engineering, Mathematics and Computer Science |
| Subject: | 53 electrotechnology |
| Programme: | Electrical Engineering MSc (60353) |
| Link to this item: | https://purl.utwente.nl/essays/101289 |
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