University of Twente Student Theses
The course of effect in the first month of biological and JAK inhibitor use in inflammatory arthritis: a real-world interim study using the Experience Sampling Method (EARLY study)
Woolderink, Lune (2024) The course of effect in the first month of biological and JAK inhibitor use in inflammatory arthritis: a real-world interim study using the Experience Sampling Method (EARLY study).
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| Full Text Status: | Access to this publication is restricted |
| Embargo date: | 30 December 2025 |
| Abstract: | Inflammatory rheumatic diseases like rheumatoid arthritis (RA), spondyloarthritis (SpA), and psoriatic arthritis (PsA) cause joint pain, stiffness, and swelling, which can vary daily. Treatments include DMARDs, with bDMARDs and tsDMARDs used when these are ineffective. Although effective, the short-term effects of these medicines and effect differences between treatment type, sex and diagnosis remains unstudied. The Experience Sampling Method (ESM) can capture real-time treatment effects and adverse drug reactions (ADRs). This study aims to assess pain, stiffness, and swelling over the first 31 days of bDMARDs or tsDMARDs treatment in RA, PsA, and SpA patients, considering treatment type, sex, and diagnosis. With observing compliance with ESM and ADRs as secondary objectives. Using a smartphone app, ESM surveyed patients twice daily for 31 days. Pain, stiffness, and swelling were rated on a 0-10 scale, with ADRs reported descriptively. Linear Mixed Models (LMMs) analyzed primary outcomes, and response rates assessed ESM compliance. Among 23 participants, data from 18 were analyzed. Significant reductions were observed in pain, stiffness, and swelling, with no significant differences between treatments, sex, or diagnosis. ESM compliance was 72.8%, and nervous system disorders were the most frequent ADRs. The interim study showed significant reductions in symptoms within 31 days of treatment, with high ESM compliance and frequent nervous system ADRs. |
| Item Type: | Essay (Master) |
| Clients: | Medisch Spectrum Twente (MST), Enschede, Netherlands |
| Faculty: | TNW: Science and Technology |
| Subject: | 44 medicine |
| Programme: | Health Sciences MSc (66851) |
| Link to this item: | https://purl.utwente.nl/essays/101418 |
| Export this item as: | BibTeX EndNote HTML Citation Reference Manager |
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