University of Twente Student Theses
The Toxicity of 3D-Printer Resin Leachates on Human Endometrial Epithelial Cells
Figge, C.K.A. (2024) The Toxicity of 3D-Printer Resin Leachates on Human Endometrial Epithelial Cells.
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| Abstract: | 3D-printing is a technology that can fabricate complex 3D-structures faster and cheaper than current technologies. In the medical world, there are developments to fabricate patient-specific prostheses with stereolithography (SLA), which is already applicable in dentistry. However, out of the 3D-printed structures, components can leach out. These leachates can influence hormonal pathways and fertility. Because of this link, this research wants to look at the repercussions of the implementation of a prosthesis near the uterus. This research has tried to 1.) establish what the toxic effects are from leachates on human endometrial epithelial cells which was assessed by considering the metabolic activity, 2.) to research which post-curing treatment is needed to minimize the amount of leachates or alleviate any, and 3.) to research if the physiological environment of the uterus enhances leaching. For this research, the commercially available resins FL Biomed, Clear and Elastic were used. The final conclusion is that the leachates released at pH 7 are less cytotoxic than the leachates released at pH 4. A post-treatment with UV-light and heat works, but it is speculated to evoke an effect of its own. More research is needed before SLA prostheses can be safely implemented in the human body. |
| Item Type: | Essay (Bachelor) |
| Faculty: | TNW: Science and Technology |
| Subject: | 42 biology |
| Programme: | Biomedical Technology BSc (56226) |
| Link to this item: | https://purl.utwente.nl/essays/102226 |
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