University of Twente Student Theses

Login

A Model for Simulation of the Neonatal Lymphatic Transport System Enhancing our understanding of the neonatal lymphatic (patho)physiology

Drijver, C. den (2024) A Model for Simulation of the Neonatal Lymphatic Transport System Enhancing our understanding of the neonatal lymphatic (patho)physiology.

[img] PDF
3MB
Abstract:Simulation models can mimic the behavior of physiological systems and therefore assist in clinical decision making. Currently, an explanatory in-silico model of a neonate is being developed at the Amalia Children's Hospital in Nijmegen, called Explain. Our goal was to create a model of the neonatal lymphatic transport system complementary to Explain. We aimed to gain better insight into lymphatic (patho)physiology and the interactions between the lymphatic system and the circulatory and respiratory systems. As described in the literature, in our model interstitial fluid is produced due to hydrostatic and osmotic pressure gradients and is taken up by the lymphatic system through extrinsic pumping. Lymph is then propelled through the lymphatic system and returned to the venous circulation via both intrinsic and extrinsic pumping. However, under pathological conditions, lymph production and drainage decreased in the long term, which does not correspond with in vivo measurements. Small adaptations to the model have been proposed to resolve these discrepancies. Our modeling effort has provided new insights into the (patho)physiology of the lymphatic system and enhanced our understanding of its interactions with other systems.
Item Type:Essay (Master)
Clients:
RadboudUMC, Nijmegen, Nederland
Faculty:TNW: Science and Technology
Subject:44 medicine, 50 technical science in general
Programme:Technical Medicine MSc (60033)
Link to this item:https://purl.utwente.nl/essays/102248
Export this item as:BibTeX
EndNote
HTML Citation
Reference Manager

 

Repository Staff Only: item control page