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Modelling the autonomic cardiac regulation: Investigating the cardiac sympathetic tone during the Valsalva Manoeuvre in healthy participants

Krijnen, E.A. (2024) Modelling the autonomic cardiac regulation: Investigating the cardiac sympathetic tone during the Valsalva Manoeuvre in healthy participants.

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Abstract:Autonomic Nervous System (ANS) disorders and cardiac problems are often interrelated. The ANS controls heart rate and maintains homeostasis of blood pressure. This study evaluated the Sympathetic Nervous System (SNS) using a novel method, Sympathetic Skin Nerve Activity (SKNA). We aimed to create an explainable model to better understand autonomic cardiac regulation, simulating Heart Rate (HR), average Skin Sympathetic Nerve Activity (aSKNA), and Electrodermal activity (EDA) response to the Valsalva Manoeuvre (VM). Two datasets were utilized, one obtained during this study, the other ealier recorded by Tertoolen. A simplified model was developed which simulated HR, aSKNA, and EDA using the timing of VM as input. The results from Study 2023 and Study 2024 were comparable. Study 2024 lacked usable EDA data. The model demonstrated adequate performance metrics on Study 2023 with R-squared values between 0.587-0.770 and NRMSEs between 0.041-0.257. The model performed slightly worse on Study 2024’s HR prediction, with an R-squared value of 0.075 and NRMSE of 0.379, exhibiting timing issues. It achieved good results for aSKNA. The predictions of the developed model showed a useful resemblance to measurements, giving insight into the role of the ANS in cardiac regulation, although further model and parameter optimization is necessary.
Item Type:Essay (Master)
Faculty:TNW: Science and Technology
Subject:31 mathematics, 42 biology, 44 medicine
Programme:Biomedical Engineering MSc (66226)
Link to this item:https://purl.utwente.nl/essays/102490
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