University of Twente Student Theses
The Use of Bioneedles in Vaccine Storage: a Hot Topic or Cold Case?
Kaal, D.F.A. (2024) The Use of Bioneedles in Vaccine Storage: a Hot Topic or Cold Case?
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| Abstract: | Most vaccines must be stored at low temperatures to keep their effectiveness. Because this requires cold transport and storage, which is expensive and not always reliable, it is of interest that an alternative solution be found. The Bioneedle is a small needle made from a biodegradable polymer that can be filled with a vaccine and transported and stored outside the cold-chain. This bachelor thesis aims to investigate the stabilizing effect of the Bioneedle material on Bovine Serum Albumin for a short period at extreme temperatures. The retention of the structure in solution and Bioneedle samples was investigated using CD spectroscopy and FT-IR spectroscopy. Although the preparation of Bioneedles caused degradation, the samples stored in Bioneedles showed less degradation when exposed to high temperatures. While the analytical methods used do provide some insight in assessing the quality of BSA, more research is required to conclusively say if it can be used as a model protein. |
| Item Type: | Essay (Bachelor) |
| Faculty: | TNW: Science and Technology |
| Subject: | 42 biology, 44 medicine |
| Programme: | Biomedical Technology BSc (56226) |
| Link to this item: | https://purl.utwente.nl/essays/103406 |
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