University of Twente Student Theses
Factors influencing the application of pathology assessment of metastasis in breast cancer
Tempelman, Marije (2024) Factors influencing the application of pathology assessment of metastasis in breast cancer.
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| Full Text Status: | Access to this publication is restricted |
| Embargo date: | 1 September 2026 |
| Abstract: | Breast cancer is the most common cancer type for women in the Netherlands. 20% of this population gets diagnosed with metastasis, either synchronous or metachronous. Guidelines stipulate that all metastases should be pathologically confirmed to exclude a second primary tumor and to determine the best treatment for the patients. This study aimed to determine differences between and factors associated with pathological confirmation of synchronous and metachronous metastases. Data from 1491 patients diagnosed with metastatic breast cancer in 2019 were extracted from the Netherlands Cancer Registry. Differences in pathological confirmation of metastasis were identified by chi square analysis. Logistic regression analyses were performed univariate and multivariate to gain insight into factors influencing the application of pathological assessment. 36.5% of all synchronous metastasis and 66.6% of all metachronous metastasis are pathologically confirmed. Metachronous metastasis has more odds of being pathologically confirmed. Other factors associated with pathological confirmation of metastasis include age of the patient, socio-economic status, the time interval between primary tumor and metastasis, morphology of the primary tumor and topography of metastasis. It was found that synchronous metastases are less likely to be pathologically confirmed compared to metachronous metastases. Factors associated with pathological confirmation are primarily patient-related. Next to that, location of the metastasis is determinative of pathological confirmation. Further research should investigate survival differences between pathological confirmation and synchronous and metachronous metastasis. |
| Item Type: | Essay (Master) |
| Faculty: | TNW: Science and Technology |
| Programme: | Health Sciences MSc (66851) |
| Link to this item: | https://purl.utwente.nl/essays/103753 |
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