University of Twente Student Theses
Antibacterial coatings for the prevention of biliary stent occlusion
Struikenkamp, Andy (2024) Antibacterial coatings for the prevention of biliary stent occlusion.
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| Abstract: | Biliary stents are placed in the common bile duct to treat biliary stenosis. Plastic biliary stents are prone to stent occlusion, where the stent becomes clogged after the formation of a biofilm. Current clinical practices suggest replacement of plastic stents every 3 to 4 months to prevent occlusion, but this decreases the quality of life of patients through repeated interventions and increases healthcare costs. Thus, there is a demand for plastic biliary stents with a longer patency. A solution to this problem is to improve the antibacterial properties of the stent surface. The work reported in this thesis focused on developing an antibacterial coating through the use of lipids. For a lipid-based coating to remain stable in bile, which is a surfactant-rich environment, stabilization of lipid coatings turned out to be required. Biliary stents were coated with various lipid formulations that remained stable in the physiological environment up to 10 days and were found to reduce initial bacterial attachment by 70-75%. |
| Item Type: | Essay (Master) |
| Faculty: | TNW: Science and Technology |
| Subject: | 35 chemistry, 44 medicine |
| Programme: | Biomedical Engineering MSc (66226) |
| Link to this item: | https://purl.utwente.nl/essays/103760 |
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