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Reorientation of inadequate resection margins to the wound bed during tongue carcinoma removal surgery

Vliet, J.T. van (2020) Reorientation of inadequate resection margins to the wound bed during tongue carcinoma removal surgery.

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Abstract:Reducing the recurrence rates for patients with oral squamous cell carcinoma is imperative for long term survival. An experimental workflow is set-up in the Netherlands Cancer Institute to combat recurrence rates. A three-dimensional ultrasound scan of a specimen is intra-operatively employed to determine whether it contains inadequate margins. If inadequate margins are found, immediate additional resection is desired. The aim of this study is to find a practical method to reorientate the inadequate margins to the wound bed and subsequently offer virtual advice to surgeons for the location of the inadequate margins. The novel method registers the three-dimensional specimen model with a two-dimensional photograph of the wound bed on basis of markers. Two separate phantom experiments found that under optimal circumstances the method estimates the location of the inadequate margins well within the desired 5 mm. The method is also assessed for three patients retrospectively. In practice, it was difficult to create optimal circumstances intra-operatively. This novel method has shown promise in phantom validation but requires improvement for future clinical implementation.
Item Type:Essay (Master)
Clients:
Unknown organization, Netherlands
Faculty:EEMCS: Electrical Engineering, Mathematics and Computer Science
Programme:Biomedical Engineering MSc (66226)
Link to this item:https://purl.utwente.nl/essays/104136
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