University of Twente Student Theses
Improving preoperative imaging for the localisation of parathyroid adenomas
Duteweert, R.J.A. (2024) Improving preoperative imaging for the localisation of parathyroid adenomas.
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| Abstract: | The goal of this research was to develop the optimal localisation protocol for patients with a suspected parathyroid adenoma (PA) in terms of number of examinations, lowest possible total radiation dose and highest localisation accuracy. The multireader, multicase (MRMC) study demonstrated that it is possible to reduce the number of phases in the 4DCT protocol from four to three while maintaining localisation accuracy. For experienced 4DCT radiologists, the number of phases could be further reduced to a two-phase 4DCT protocol. An enhancement map was developed to increase the detectability of PAs, but despite a promising quantitative analysis and promising feedback from radiologists, no increased detectability of parathyroid adenomas was observed during the MRMC study. Finally, the developed 18F-Choline PET/4DCT protocol has proven to be a promising ‘one-stop shop’ alternative to the currently used imaging protocols in terms of image quality and radiation dose. The patient benefits from the proposed 4DCT protocols, since the radiation dose can be reduced compared to the currently used four-phase 4DCT protocol. The 18F-Choline PET/4DCT protocol may further improve patient comfort, since less hospital visits are required to localise the PA. |
| Item Type: | Essay (Master) |
| Clients: | Rijnstate Hospital, Arnhem, Netherlands |
| Faculty: | TNW: Science and Technology |
| Subject: | 44 medicine |
| Programme: | Technical Medicine MSc (60033) |
| Link to this item: | https://purl.utwente.nl/essays/104638 |
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