University of Twente Student Theses
Integrating Compact Electrochemical Measurement Readouts on a Modular Organ-on-Chip Platform
Nijenhuis, Wouter (2024) Integrating Compact Electrochemical Measurement Readouts on a Modular Organ-on-Chip Platform.
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| Full Text Status: | Access to this publication is restricted |
| Embargo date: | 31 December 2025 |
| Abstract: | The demand for Organ-on-Chip systems has risen due to a shift away from animal testing and the need to make more complex cell culture systems. A modular platform is being designed using the ISO 22916:2022 standard to advocate standardization within the field. It strives to be a true lab-on-chip and not chip-in-a-lab system by integrating microfluidics and electronics within the size of a multiwells plate, which reduces the number of external connections needed. The goal of this master's project is to reduce further the external connections needed by designing a way of integrating electrochemical sensor read-out onto the modular platform. The device's design is chosen as a modular one-cable solution using the EmStat Pico module from PalmSens integrated on a PCB. The device's footprint is 35 x 38 mm and can fit on top of a 30 x 30 mm microfluidic building block. Proof-of-concept measurements are carried out using a three-electrode setup with platinum working and counter electrodes and a quasi-reference Ag/AgCl electrode. Electrical impedance spectroscopy is used to show a difference in KCl concentration. Differences in oxygen concentration are shown in cyclic voltammetry and chronoamperometry. With the device integrated on the platform, the experiments show successful electrochemical measurements for monitoring Organ-on-Chip system parameters. |
| Item Type: | Essay (Master) |
| Faculty: | EEMCS: Electrical Engineering, Mathematics and Computer Science |
| Subject: | 35 chemistry, 50 technical science in general, 53 electrotechnology |
| Programme: | Electrical Engineering MSc (60353) |
| Link to this item: | https://purl.utwente.nl/essays/104741 |
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