University of Twente Student Theses
Biomimetic Eccentric Action through Mechanical and Electrical Stimulation of Nitinol : Strain Velocity Control Using Long Short-Term Memory Neural Networks
Venekamp, J.Q. (2024) Biomimetic Eccentric Action through Mechanical and Electrical Stimulation of Nitinol : Strain Velocity Control Using Long Short-Term Memory Neural Networks.
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| Full Text Status: | Access to this publication is restricted |
| Embargo date: | 1 December 2029 |
| Abstract: | Skeletal muscle tissue engineering is essential for accurately modeling muscular diseases and drug development. Skeletal muscles are highly adaptable and responsive to biophysical cues. However, the application of physiologically relevant tissue stimulation remains underexplored. This study introduces an advanced contraction platform that allows mechanical and electrical stimulation of nitinol, a shape memory alloy, as a tissue surrogate. We developed two strain velocity control methods to recreate eccentric contractions: a nominal PI-control-based model and an extended model incorporating a Long Short-Term Memory (LSTM) Neural Network as a disturbance observer. Both models were evaluated on twelve different eccentric training schedules relating to 10%, 15%, and 20% strain application. The nominal control model showed reliable recreation of all schedules, reaching fast settling times of 0.32 s and low steady-state errors of -0.48 μm/s. In contrast, the LSTM model showed variable predictive performance, with an average validation R2 score of 0.882 and a high RMSE score of 24.42 μm/s. The study successfully demonstrates the novel recreation of biomimetic eccentric contractions through combined electrical and mechanical stimulation of nitinol. This work provides proof-of-concept for future research in biomimetic eccentric contractions, allowing advancements in in-depth muscle adaptation and regeneration studies. |
| Item Type: | Essay (Master) |
| Faculty: | ET: Engineering Technology |
| Subject: | 30 exact sciences in general, 50 technical science in general, 52 mechanical engineering |
| Programme: | Biomedical Engineering MSc (66226) |
| Link to this item: | https://purl.utwente.nl/essays/104776 |
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