University of Twente Student Theses
Low frequency DBS-evoked potentials in patients with epilepsy : a sensor and source space analysis
Bay, Jill (2024) Low frequency DBS-evoked potentials in patients with epilepsy : a sensor and source space analysis.
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Abstract: | This study examined low-frequency anterior nucleus of the thalamus (ANT)-deep brain stimulation (DBS) and its effects on evoked potentials (EPs) in patients with drug-resistant epilepsy (DRE). The focus was on how DBS parameters, such as amplitude, contact, and implantation, modulate EPs characterized by latency, magnitude, and source location. The aim was to explore the mechanisms of low-frequency ANT-DBS and its impact on related neural networks. Data from two subjects in the EANSkE study were analyzed, including EEG recordings and T1-/T2-weighted images. Preprocessing techniques included template subtraction to reduce DBS artifacts and dipole fitting to locate sources. The effects of DBS parameters were investigated using Global Mean Field Power (GMFP) plots, topographical maps, and source-level dipole reconstructions. Anatomical labels were assigned using the Brainnetome atlas. Results showed clear EP components at 3-10 ms, 19-26 ms, 37-58 ms, and 55-117 ms. Deeper contacts (C0, C1) and higher amplitudes produced stronger responses. Dipoles moved temporally along the Papez circuit, including the thalamus, cingulate gyrus, and basal ganglia. While limited by sample size and reconstruction accuracy, this study highlights how DBS parameters modulate neural activity and emphasizes the potential of targeted neuromodulation to influence seizure networks. |
Item Type: | Essay (Master) |
Faculty: | EEMCS: Electrical Engineering, Mathematics and Computer Science |
Subject: | 53 electrotechnology |
Programme: | Electrical Engineering MSc (60353) |
Link to this item: | https://purl.utwente.nl/essays/104834 |
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