University of Twente Student Theses
Early cost effectiveness analysis of oral immunotherapy for young children with peanut allergy
Boer, Daan (2025) Early cost effectiveness analysis of oral immunotherapy for young children with peanut allergy.
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| Abstract: | Peanut allergy represents a significant health and economic burden, particularly in young children, with limited treatment options currently available. This study assesses the cost-effectiveness of low-dose oral immunotherapy (OIT) compared to the standard of care (SOC) for Dutch children under 30 months. A health state transition model was developed to simulate a cohort over a 25-year horizon, incorporating treatment effects, adherence, and age-specific transitions. Costs and quality-adjusted life years (QALYs) were evaluated from patient, caregiver, and societal perspectives. Multiple scenarios were analysed to address uncertainties in key assumptions. Results indicate that from a societal perspective OIT is both cost-saving and improves QALYs across all scenarios compared to SOC. Scenario 3, assuming sustained adherence post-desensitization, yielded the greatest QALY gain (+0.644) and cost savings (€75,030) from a societal perspective. Deterministic and probabilistic sensitivity analysis emphasized adherence as a key determinant of costs and health outcomes. This exploratory analysis suggests that early initiation of OIT is a cost-effective strategy for managing peanut allergies in young children, with the potential to improve health outcomes and reduce societal costs. Further research is recommended to validate these results and address uncertainties related to long-term effects and adherence to regular ingestion of peanut after OIT treatment. |
| Item Type: | Essay (Master) |
| Clients: | Deventer Ziekenhuis, Deventer, Netherlands |
| Faculty: | TNW: Science and Technology |
| Subject: | 44 medicine |
| Programme: | Health Sciences MSc (66851) |
| Link to this item: | https://purl.utwente.nl/essays/104857 |
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