University of Twente Student Theses
Targeting inflammatory macrophages using bioactive liposomes to ameliorate MASLD : an in vivo biodistribution study in MASLD mouse model
Bosi, Marco (2025) Targeting inflammatory macrophages using bioactive liposomes to ameliorate MASLD : an in vivo biodistribution study in MASLD mouse model.
|
PDF
6MB |
| Abstract: | Metabolic dysfunction-associated steatotic liver disease (MASLD), previously called non alcoholic fatty liver disease (NAFLD), is a prevalent metabolic condition with limited targeted treatment options. As a conclusive step in a broader project, this study explored the use of bioactive liposomes to deliver anti-inflammatory agents directly to the liver and evaluated their biodistribution and uptake in a MASLD mouse model. Cell uptake was investigated within kupffer cells, monocytes-derived macrophages and lipid-associated macrophages. Among the four liposome formulations tested, all showed significant liver accumulation, with disputable preferential uptake. Limitations such as variability in cellular uptake across different macrophage subsets and the short-term nature of the study warrant further research to optimize liposomal design and improve methodology. These findings highlight liposomes as a promising but evolving tool for MASLD management. |
| Item Type: | Essay (Master) |
| Faculty: | TNW: Science and Technology |
| Programme: | Biomedical Engineering MSc (66226) |
| Link to this item: | https://purl.utwente.nl/essays/105003 |
| Export this item as: | BibTeX EndNote HTML Citation Reference Manager |
Show download statistics for this publication
Show download statistics for this publicationRepository Staff Only: item control page