University of Twente Student Theses
Stimulating Sleep: Exploring the Impact of Vagus Nerve Stimulation on Sleep in Long-Term EEG Recordings
Fledderus, Susan K. (2025) Stimulating Sleep: Exploring the Impact of Vagus Nerve Stimulation on Sleep in Long-Term EEG Recordings.
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| Full Text Status: | Access to this publication is restricted |
| Embargo date: | 5 February 2030 |
| Abstract: | Vagus Nerve Stimulation (VNS) is used to reduce seizures in pharmacoresistant epilepsy, but its effects on sleep remain unclear. This study analyzed long-term continuous EEG data from the PREDYct study, comparing a two-month baseline without VNS to up to 13 months of treatment data. Sleep changes were assessed through power spectral analysis, deep sleep duration (DSD) estimation, and two machine learning sleep scoring algorithms (SleepyCo and UNEEG). Results showed no significant changes in power measures. DSD varied in two of nine patients but lacked consistent trends. The SleepyCo algorithm found no significant changes in sleep architecture, while the UNEEG algorithm suggested possible alterations in some patients, though inconsistently. Contrary to previous studies, VNS did not consistently impact sleep architecture or spectral features, indicating effects may be subtle or patient-specific. The study highlights the limitations of automated sleep scoring for epilepsy patients and emphasizes the need for more tailored approaches. Future research with refined algorithms could provide clearer insights into the individual variability of VNS effects on sleep. |
| Item Type: | Essay (Master) |
| Faculty: | TNW: Science and Technology |
| Subject: | 44 medicine |
| Programme: | Biomedical Engineering MSc (66226) |
| Link to this item: | https://purl.utwente.nl/essays/105256 |
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