University of Twente Student Theses
Building a visualisation tool for an organ-on-a-chip model of fibrotic diseases
Broek, E.M. van den (2025) Building a visualisation tool for an organ-on-a-chip model of fibrotic diseases.
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| Abstract: | Fibrotic disorders, responsible for approximately 45% of deaths in developed countries, present significant challenges in medical research and treatment development. While organ-on-chip (OoC) technology offers promising alternatives to traditional research models for studying fibrosis, their microscopic size and maintenance requirements limit their use in educational and communication contexts. This study aimed to develop and evaluate an interactive visualisation tool to enhance understanding of organ-on-chip models and fibrosis, addressing how 3D digital visualisation tools can effectively illustrate fibrotic disease progression and accurately represent organ-on-chip models. The project began with literature research to understand the biological and technological aspects of fibrosis and OoC. Based on this, the ideation and specification phases led to the visualisation tool. During the realisation phase, a hybrid interactive tool combining elements of a game with a structured educational experience was created. This tool utilised interactive 3D models, animations, and dialogue systems to explain the concept of fibrosis and introduce the OoC model. The evaluation phase involved user testing with eleven participants across different age groups, educational backgrounds, and levels of medical knowledge. Results showed that the tool was effective in educating users about fibrosis and the organ-on-chip model. The System Usability Scale score of 76.67 indicated good usability. The tool successfully communicated complex scientific concepts to users with varying levels and types of expertise, with participants particularly valuing the freedom to explore and step-by-step learning process. In conclusion, this study demonstrates that interactive 3D visualisations can bridge the gap between complex biological processes and advanced technological developments, making them more accessible for educational communication. The tool effectively supported learning outcomes, proving useful in enhancing understanding of fibrotic disease and organ-on-chip technology. Future developments should focus on improving the platform's adaptability to various user levels and expanding its scope to cover additional organ systems and fibrosis types. |
| Item Type: | Essay (Bachelor) |
| Faculty: | EEMCS: Electrical Engineering, Mathematics and Computer Science |
| Subject: | 42 biology, 54 computer science, 81 education, teaching |
| Programme: | Creative Technology BSc (50447) |
| Link to this item: | https://purl.utwente.nl/essays/105990 |
| Export this item as: | BibTeX EndNote HTML Citation Reference Manager |
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