University of Twente Student Theses
Sleep spindles as biomarker for cognitive decline in children with Developmental and/or Epileptic Encephalopathy with Spike-Wave Activation in Sleep
Broeke, T.R. and Dongen, C.A. van and Roos, S. de and Vennekens, H. (2025) Sleep spindles as biomarker for cognitive decline in children with Developmental and/or Epileptic Encephalopathy with Spike-Wave Activation in Sleep.
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| Abstract: | Cognitive and behavioural decline contribute to a diagnosis of developmental and/or epileptic encephalopathy with spike-wave activation in sleep (DEE-SWAS) and affects the daily life of children. A new biomarker is needed to monitor cognitive decline in children with DEE-SWAS, since the current spike-wave index (SWI) is not clearly related to intelligence quotient tests, through which cognitive decline is measured. Therefore, we investigated sleep spindles. We compared this with the correlation between SWI and cognition. Our research question was: ”Is the correlation between sleep spindles and cognition higher than the correlation between SWI and cognition?”. A retrospective observational study was conducted. We analysed the correlation with sleep spindle characteristics (spindle rate, duration and frequency) with the Spearman correlation. We found no evidence that sleep spindles have a higher correlation with cognition compared to SWI. All Spearman correlations have no significant results. The low sample size, spindle and sleep annotation criteria by SleepRT and chosen definitions for spindle frequencies may be contributing factors to this result. For future research, we recommend exploring different algorithms for sleep spindle annotation and including more EEGs. These efforts may ultimately help improve diagnosis and treatment strategies for children with DEE-SWAS. |
| Item Type: | Student Thesis (Bachelor) |
| Faculty: | TNW: Science and Technology |
| Subject: | 44 medicine |
| Programme: | Technical Medicine BSc (50033) |
| Link to this item: | https://purl.utwente.nl/essays/106641 |
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