University of Twente Student Theses
Microwave Ablation for Lung Tumours up to 3 cm : Influencing Factors and Lessons Learnt from Liver Ablation and Clinical Expertise
Hogewoning, S.G. and Speksnijder, H.H.W and Kaak, D.A.W. and Kamphuis, J.C. (2025) Microwave Ablation for Lung Tumours up to 3 cm : Influencing Factors and Lessons Learnt from Liver Ablation and Clinical Expertise.
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| Abstract: | Microwave ablation (MWA) is a well-established technique for treating hepatic tumours. However, its application in the lung presents distinct challenges due to differences in anatomy and physiology. This can lead to altered ablation dynamics and clinical outcomes, rendering direct application of liver protocols inadequate. To better understand how MWA can be applied effectively in the lungs, this ex- ploratory study examines what can be learnt from the practice of MWA in the liver. To understand lung MWA and its limitations, this paper provides an overview of the key factors that influence the use of MWA in lung tissue. In addition, we address the procedural and technical challenges encountered in liver MWA, including imaging dependency, ablative margin requirements, complication management and the critical role of patient selection and assess their relevance in the context of lung ablation. Segmentation of both the tumour and the associated ablation zone allows evaluation of the efficacy of the treatment in pulmonary ablation, facilitating a direct comparison with established hepatic outcomes. The under- estimated ablation zone, combined with the single-lung ventilation and higher heating rates, leads to the conclusion that MWA can be done in a shorter period of time and lung damage can be minimised while providing more spherical ablation zones, potentially improving treatment outcomes. This study shows that key anatomical and physiological differences between the liver and lung considerably influence the effectiveness and predictability of the MWA procedure and that standardised procedures based on consensus and attention to tissue differences are needed. |
| Item Type: | Student Thesis (Bachelor) |
| Clients: | Radboud UMC, Nijmegen, Netherlands UMCG, Groningen, Netherlands |
| Faculty: | TNW: Science and Technology |
| Subject: | 44 medicine |
| Programme: | Technical Medicine BSc (50033) |
| Link to this item: | https://purl.utwente.nl/essays/106651 |
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