University of Twente Student Theses
As of Friday, 8 August 2025, the current Student Theses repository is no longer available for thesis uploads. A new Student Theses repository will be available starting Friday, 15 August 2025.
Implementation of the baroreflex-mediated venoconstriction component in a maternal hemodynamic lumped-compartment model
Gille, S. and Hoepelman, T. and van Spaandonk, M. and Kleinhout, L. (2025) Implementation of the baroreflex-mediated venoconstriction component in a maternal hemodynamic lumped-compartment model.
Full text not available from this repository.
| Full Text Status: | Access to this publication is restricted |
| Abstract: | Objective: Maternal hemodynamic changes during pregnancy are critical for ensuring healthy outcomes. Understanding and predicting these changes is essential for the early detection of complications, such as pre-eclampsia. Mathematical models provide valuable insights into human physiology and support clinical decision-making. Radboudumc is developing a hemodynamic lumped-compartment model to simulate maternal hemodynamic changes. This study aims to implement the baroreflex-mediated venoconstriction component in this hemodynamic model to improve its ability to simulate maternal blood pressure regulation. Methods: The venoconstriction component was added to the hemodynamic model by incorporating venous compliance and unstressed volume. Five model configurations were evaluated: a baseline model, a control model without baroreflex, and three models incorporating either venous compliance, unstressed volume or both. Simulations included a head-up tilt test to evoke baroreflex responses. Primary outcome parameters were aortic pressure, heart rate, stroke volume, cardiac output, vena cava pressure, and baroreflex control factors. For validation, the model outputs were compared with clinical data of 44 healthy non-pregnant women. Results: Simulations showed that the models incorporating baroreflex-mediated adjustments showed improved blood pressure regulation compared to the control model. These models maintained a higher aortic pressure and improved better alignment with clinical data. Conclusion: The incorporation of the venous compliance and unstressed volume brought the model one step closer to a complete representation of the baroreflex. This advancement not only enhances the model's physiological accuracy, but also led to new research directions. It contributed to the goal of Radboudumc for clinical application in studying, predicting and simulating (patho)physiological changes during pregnancy. |
| Item Type: | Essay (Bachelor) |
| Clients: | Radboudumc, Nijmegen, Netherlands |
| Faculty: | TNW: Science and Technology |
| Subject: | 44 medicine, 50 technical science in general |
| Programme: | Technical Medicine BSc (50033) |
| Link to this item: | https://purl.utwente.nl/essays/106976 |
| Export this item as: | BibTeX EndNote HTML Citation Reference Manager |
Show download statistics for this publication
Show download statistics for this publicationRepository Staff Only: item control page