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A normative PD-specific brain template derived from 230 patients for optimizing analysis in deep brain stimulation for Parkinson’s disease : The NTN-PD-DBS-230 brain template
Birnie, E. (2025) A normative PD-specific brain template derived from 230 patients for optimizing analysis in deep brain stimulation for Parkinson’s disease : The NTN-PD-DBS-230 brain template.
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| Abstract: | Deep brain stimulation of the subthalamic nucleus (STN-DBS) is an accepted therapy for Parkinson’s disease (PD). Research to improve STN-DBS requires a brain template that serves as a common space to perform group analyses. Existing templates are unsuitable for STN-DBS-eligible patients due to the population, sample size and MRI sequence they are based on. To address this, the NTN-PD-DBS-230 brain template was developed, based on MRI data from 230 patients who underwent STN-DBS-surgery at the Radboudumc. The template is available in both a T1-weighted and T2-weighted version with isotropic resolutions of 1.1 mm and 0.5 mm. Evaluation showed superior inter-subject similarity compared to 12 of 14 existing templates (p<0.0003). The T2-weighted 0.5 mm version also outperformed five of eight templates in atlas-based segmentation accuracy (p<0.001). These results demonstrate that the PD-DBS more accurately represents the anatomy of STN-DBS-eligible PD patients and offers improved registration performance. While promising, further recommendations include updating the high-resolution template, external validation and re-assessment of data saturation. With these improvements, the PD-DBS template has the potential to become a new standard reference space for research and clinical applications in STN-DBS for PD, supporting more accurate and personalized treatment strategies. |
| Item Type: | Essay (Master) |
| Clients: | Radboudumc, Nijmegen, The Netherlands |
| Faculty: | TNW: Science and Technology |
| Subject: | 44 medicine, 50 technical science in general |
| Programme: | Technical Medicine MSc (60033) |
| Link to this item: | https://purl.utwente.nl/essays/107193 |
| Export this item as: | BibTeX EndNote HTML Citation Reference Manager |
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