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The LSCI Calibration Constant: Influence of Calibration Phantom Properties, System Parameters and External Noise
Iersel, Isabel van (2025) The LSCI Calibration Constant: Influence of Calibration Phantom Properties, System Parameters and External Noise.
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| Abstract: | Laser Speckle Contrast Imaging, a technique based on speckle interference, is used to non-invasively visualize blood flow, by relating the speckle interference to contrast and eventually perfusion. However, it is still unknown to what degree system parameters, external noise and calibration phantom properties influence the system constant Beta and thus the measured contrast. In practice, this may lead to over- or underestimation of perfusion. Phantoms consisting of Intralipid for scattering, Ecoline ink for absorption and agar to make them static, were fabricated to determine changes in contrast due to varying absorption and reduced scattering coefficients. Besides that, the effect of an extra polarizer and external noise such as outdoor light were also included. Contrast measurements showed that an increasing from 0.9 to 2.1 [\mm] reduced scattering coefficient, showed a decrease in contrast from 0.82 to 0.66. This was accompanied by an increasing intensity per pixel. For the increasing absorption coefficient, the results were inconclusive, due to the incomplete dissolution of agar. The extra polarizer approximately enhanced the contrast with 0.1 and outdoor light disturbed and lowered the contrast by approximately 0.05. Further research is necessary to determine the influence of variation in absorption coefficient and laser intensity. |
| Item Type: | Essay (Bachelor) |
| Faculty: | TNW: Science and Technology |
| Subject: | 50 technical science in general |
| Programme: | Biomedical Technology BSc (56226) |
| Link to this item: | https://purl.utwente.nl/essays/107878 |
| Export this item as: | BibTeX EndNote HTML Citation Reference Manager |
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