Integrating patient preferences and clinical trial data in an MCDA model for quantitative benefit-rik assessment

Broekhuizen, Henk (2012) Integrating patient preferences and clinical trial data in an MCDA model for quantitative benefit-rik assessment.

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Abstract:This study shows that it is possible to integrate elicited patient preferences and clinical data in a quantitative model for benefit-risk assessment. The model can handle preference information from AHP and conjoint analysis studies and performance information from clinical trials and systematic reviews. It can assess the impact of the uncertainty around parameters by simulating the problem with approximated joint distributions. The graphs that can be produced with the model can give an overview of the characteristics of the problem, structuring the available evidence for regulators. We tested the model in two cases which served to illustrate our model. It is important that modellers, regulators and clinical experts collaborate in real-life applications of quantitative models like this. This is especially important during the first stages of modelling, when the model structure is decided, data is selected and assumptions are made.
Item Type:Essay (Master)
Faculty:BMS: Behavioural, Management and Social Sciences
Subject:85 business administration, organizational science
Programme:Health Sciences MSc (66851)
Link to this item:http://purl.utwente.nl/essays/62038
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