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The Bioartificial Pancreas "A Clinical Case Scenario Analysis to assess and support the development of a device to improve type I Diabetes care".

Wissing, T.B. (2012) The Bioartificial Pancreas "A Clinical Case Scenario Analysis to assess and support the development of a device to improve type I Diabetes care".

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Abstract:ABSTRACT Aims The aims of this study are to identify the most important transplantation characteristics and to asses type I Diabetes Mellitus patients’ and endocrinologists´ preferences for three potential bio-artificial pancreas (BAP) scenarios in order to guide further BAP development. Methods Attributes that determine transplant decision making were analysed based on literature search, semi-structured interviews and focus groups. The analytic hierarchy process was used to obtain relative importance weights for each defined attribute in patients (n=21) and endocrinologists (n=12). With these weights, overall preferences for three potential BAP scenarios were calculated and compared to conventional transplantation methods. Results The most important attributes are the effectiveness of the transplant, patient safety and the surgical procedure. However, there are considerable differences between patients and endocrinologists in the importance of effectiveness and safety. Considering these preferences, all three BAP scenarios gained a higher overall preference in comparison to conventional islet transplantation. Conclusions This study indicates the prospects of BAP development and highlights the discrepancies between endocrinologists’ and patients’ preferences. In the future, BAP developers can review their BAP design, in view of patient safety and clinical performance.
Item Type:Essay (Master)
Faculty:BMS: Behavioural, Management and Social Sciences
Subject:44 medicine
Programme:Health Sciences MSc (66851)
Link to this item:http://purl.utwente.nl/essays/64963
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