University of Twente Student Theses


Contrast agents for continuous wave photoacoustics

Linnartz, Erik Christian (2014) Contrast agents for continuous wave photoacoustics.

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Abstract:Photoacoustic imaging is a widely investigated imaging method that allows for clear differentiation between different tissues (specificity). Contrast bubble enhanced ultrasound imaging is already used a lot and despite less specificity, the bubbles create great contrast. In this report we investigate the possibilities of using contrast bubbles in combination with photoacoustics in order to combine the advantages of both methods. Contrast agents are investigated for photoacoustic imaging with a continuous wave laser. We show that polymeric microcapsules, that proved to be an effective contrast agent for pulsed laser photoacoustics, also work with a modulated continuous wave laser but require a high laser power. Oil coated microbubbles are suggested as a new contrast agent for continuous wave photoacoustics and numerical simulations are performed to find out what the optimal parameters and material properties for this contrast agent would be. A simplified model provides physical understanding of the simulated results. We also show current work in the process towards producing these contrast agents in micro-fluidic devices.
Item Type:Essay (Master)
Faculty:TNW: Science and Technology
Subject:33 physics
Programme:Applied Physics MSc (60436)
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