Supercritical CO2 decellularized porcine pericardium is a promising material for an ascending aortic prosthesis

Boer, E.C. de and Geldof, F. and Gerritse, T.J. and Winkelhorst, E.W. (2015) Supercritical CO2 decellularized porcine pericardium is a promising material for an ascending aortic prosthesis.

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Abstract:The current treatment of aneurysms and dissections is a replacement of the diseased part by a synthetic Dacron prosthesis. The elasticity of a Dacron prosthesis, however, is not even close to the elasticity of the aorta and it cannot grow with the body. A potentially better prosthetic material is scCO2 decellularized pericardium. Our aim is to research whether porcine pericardium, decellularized with scCO2, is suitable as a material for an ascending aortic prosthesis. To answer this we came up with subquestions, which we answered with literature research and two experiments. We researched the influence of repetitive stress on pericardium with an Abiomed pump for two hours. In our second experiment we investigated the difference between the fulfillment of the Windkessel function by pericardium and Dacron. The pericardial prosthesis has a 7% decrease in thickness during Measurement 1 and a 33% decrease during Measurement 2. Experiment 2 showed that pericardium decreases the pulse pressure with approximately 30 mmHg, while Dacron increases the pulse pressure with approximately 29 mmHg at different prevailing pressures. scCO2 decellularized porcine pericardium is a promising alternative for a Dacron prosthesis. We therefore strongly recommend more research about the suitability of this material for an ascending aortic prosthesis.
Item Type:Essay (Bachelor)
Faculty:TNW: Science and Technology
Subject:44 medicine
Programme:Technical Medicine BSc (50033)
Link to this item:http://purl.utwente.nl/essays/67245
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