The influence of the cold pressor test on the cerebral blood flow

Dam, J. ten and Numan, L. and Scheeren, M. and Werff, L.C.M. van de (2015) The influence of the cold pressor test on the cerebral blood flow.

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Abstract:Introduction: Response of cerebral hemodynamics to a transient elevation of blood pressure is not fully understood. Cold pressor test provokes such an elevation due to activation of sympathetic pathways. It may be a good standard stimulus in order to study cerebral hemodynamics. Objective: The physiological effects of the cold pressor test on the cerebral blood flow is not fully known. In order to provide more insights, the effect of the cold pressor test on the blood flow on three levels will be studied: carotid artery, middle cerebral artery (MCA) and the cerebral microvasculature. Methods: Ultrasound, transcranial Doppler, Time-of-Flight angiography, near infrared spectroscopy and arterial spin labelling will be used to quantify the flow in healthy subjects. Results: The flow in the left carotid artery (+5.44%), CBFV in the MCA (+6.36%) increased during the cold pressor test and an increase in oxygenated hemoglobin (oxy-Hb) of 1.32 µmol/L was found in the microvasculature of the frontal cortex. Conclusion: This research showed that the cold pressor test induced an increase in flow on all observed levels. Also, is was found that there was a time correlation between the CBFV in the MCA and the flow in the cerebral microvasculature of the frontal cortex.
Item Type:Essay (Bachelor)
Faculty:TNW: Science and Technology
Subject:44 medicine
Programme:Technical Medicine BSc (50033)
Link to this item:http://purl.utwente.nl/essays/67251
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