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Organs-on-chips : exploring the utility of biosynthesised organ tissue to improve efficiency of the drug development process

Middelkamp, H.H.T. (2015) Organs-on-chips : exploring the utility of biosynthesised organ tissue to improve efficiency of the drug development process.

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Abstract:Drug development is an expensive process, partly because of the required testing for human toxicity and efficacy of drugs. Organ-on-a-chip is a multichannel 3D microfluidic cell culture chip that simulates the activities and mechanics of entire organs and organ systems. Organ-on-chip is expected to reduce the amount of animal testing, and may increase efficiency of drug development. For instance, when organ-on-a-chip is used to replace or added to in vivo testing experiments, 7.5-10% of drug development costs may be saved. This study explores the expected advantages of organ-on-chip technologies as well as potential barriers to implement.
Item Type:Essay (Master)
Faculty:BMS: Behavioural, Management and Social Sciences
Subject:02 science and culture in general
Programme:Health Sciences MSc (66851)
Link to this item:http://purl.utwente.nl/essays/67808
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