Determining the Feasibility of Cerenkov Luminescence Imaging in Surgical Oncology

Poel, MSc R. (2015) Determining the Feasibility of Cerenkov Luminescence Imaging in Surgical Oncology.

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Abstract:Background: Surgical oncology is still one of the main treatments for curing cancer. For a successful surgery however, a clean and radical resection is required. This can only be obtained if there is precise knowledge on were the tumor is situated and what parts of the tissue are malignant and which are not. To localize a tumor a lot of techniques are available. Peroperative determination if a tissue is malignant or benign is still a challenge. To be able to do this a technique is required that is fast, implementable in the OR and foremost is tumor specific. Cerenkov Luminescence Imaging (CLI) combines optical imaging with tumor specific PET tracers such as 18F-FDG. Within biological tissue these tracers send out a very faint luminescence which can be detected with highly sensitive EMCCD cameras. This will make it a promising technique that might be able to visualize tumors during surgery. Purpose: In this study we are trying to determine if CLI is a feasible technique for peroperative tumor visualization. Methods: Different in vitro studies are performed to determine the characteristics of Cerenkov luminescence and to predict the sensitivity of CLI. Different cameras have been tested to be able to come up with the best CLI setup with the highest sensitivity. The technique was tested in 5 subjects who had a superficial tumor and subsequently had undergone an 18F-FDG PET/CT scan. Images with the CLI setup, containing an EMCCD camera, where made 4 cm from the skin where the tumor was situated. Thereafter the obtained images were processed to see if the Cerenkov light from the tumor was detected. Results: We were able to visualize an activity of 3.5 kBq/ml in vivo. On average a tumor takes up around 10 kBq/ml. However, the biological tissue absorbs the majority of the light. We were not able to detect any light coming from the 18F-FDG during the in vivo studies. Conclusion: Image guided surgery based on Cerenkov Imaging is theoretically very promising. However, the reality is that the intensities of the signal are too weak to use for in vivo imaging during surgery.
Item Type:Essay (Master)
Faculty:TNW: Science and Technology
Subject:33 physics, 44 medicine, 50 technical science in general
Programme:Technical Medicine MSc (60033)
Link to this item:http://purl.utwente.nl/essays/68119
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