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Development of a contrast enhanced ultrasound technique for the measurement of cerebral blood flow in patients with acute brain injury at the intensive care unit

Vinke, MSc E.J. (2015) Development of a contrast enhanced ultrasound technique for the measurement of cerebral blood flow in patients with acute brain injury at the intensive care unit.

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Abstract:Monitoring the cerebral blood flow (CBF) is essential for neurocritical care. However, easy, non-invasive and reliable direct bedside monitoring of the CBF is not feasible at this moment in the ICU. Contrast enhanced ultrasound (CEUS) is a promising technique for this purpose. The aim of this study is to determine the repeatability of the bolus kinetic and to determine the correlation between the blood flow velocity measured with duplex and the perfusion parameters of the bolus technique at different CBF. A study was performed on 10 young healthy volunteers. CEUS was performed three times during baseline and once during mild hyperventilation. The CEUS parameter TPI had the lowest CV in the MCA region with a value of 13.7%. In the three parenchyma regions the parameter with the lowest CV is TPI with a value of 6.1% and 9.7%. All other parameters had a CV >10%. We conclude that the CEUS parameters have poor repeatability, except for the TPI in the parenchyma regions. The poor repeatability corresponds with the high variation in CEUS outcome described in literature. For the quantification of the CBF we believe that the poor repeatability within the same individual is the most important limitation of this technique.
Item Type:Essay (Master)
Faculty:TNW: Science and Technology
Subject:44 medicine
Programme:Technical Medicine MSc (60033)
Link to this item:http://purl.utwente.nl/essays/68233
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