Aspects in a clinical environment and probe design influencing mangetometer performance during sentinel lymph node biopsy

Bastiaan, D.M.C. (2015) Aspects in a clinical environment and probe design influencing mangetometer performance during sentinel lymph node biopsy.

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Abstract:In metastatic breast cancer, sentinel lymph node (SLN) status is essential to establish staging and determining prognosis, since SLNs are the first nodes to receive drainage from the primary tumor. The SNMMI and EANM set up a guideline for SLN localization requiring a detector to identify weakly active SLNs attenuated by 5 cm of soft tissue. A radiation-free method for SLNB is magnetic sentinel lymph node biopsy (SLNB). Intraoperatively injected superparamagnetic tracer particles (Sienna+) are localized via a handheld magnetometer for transcutaneous localization. Magnetometer systems are not only sensitive to the magnetic tracer but are to the diamagnetic tissue. Little is known about the influence of this tissue contribution on the detection of SLNs. The goals of this thesis were to quantify the aspects influencing magnetometer performance in a clinical environment during SLNB. And to optimize probe design in order to improve magnetometer performance during SLNB. To achieve these goals, a phantom similar to breast tissue was developed. Multiple magnetometer systems were evaluated including the commercially available SentiMag (first and second generation) and the handheld DiffMag. Moreover, simulations were performed to examine the probe design modifications necessary for SLN localization in accordance with the SNMMI and EANM guideline.
Item Type:Essay (Master)
Faculty:TNW: Science and Technology
Subject:33 physics
Programme:Biomedical Engineering MSc (66226)
Link to this item:http://purl.utwente.nl/essays/68957
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