University of Twente Student Theses


The diagnostic properties of enzym based diagnostics of infections in diabetic foot ulcers

Lieshout, C. van (2016) The diagnostic properties of enzym based diagnostics of infections in diabetic foot ulcers.

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Abstract:Diabetic foot ulcers are a common complication for patients with diabetes. Foot ulcers, like all chronic wounds, are prone to infection. Clinical signs and symptoms are used to diagnose infection and wound swabs for microbiological analysis are used when infection is suspected. Wound swabs are accurate but results take time. Lysozyme is an enzyme secreted by neutrophils when fighting infection. A diagnostic tool based on lysozyme may improve the diagnostic process. The aim of this study was to determine the diagnostic properties of lysozyme in diabetic foot ulcers (DFU) compared to microbiological analysis as gold standard. The secondary aim was to identify a relation between lysozyme and clinical outcome after four weeks. Sixty chronic wounds, both DFU and non-DFU wounds, were evaluated for signs and symptoms and swabs for both microbiological analysis and enzyme analysis were taken. Thirty-nine patients had DFU (61.5%). Lysozyme performed slightly better in non-DFU wounds compared to DFU. Results on secondary outcomes show lysozyme may be promising to function as an early detection method when compared to clinical outcome after four weeks. Lysozyme seems to be a promising method to diagnose infections, more research and substrate refinement is necessary to draw reliable conclusions.
Item Type:Essay (Bachelor)
Medisch Spectrum Twente, Enschede, Nederland
Faculty:TNW: Science and Technology
Subject:44 medicine
Programme:Health Sciences BSc (56553)
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