In depth analysis of biological tissue characteristics of uterine fibroids using new MRI techniques.

Slouwerhof, Inge (2016) In depth analysis of biological tissue characteristics of uterine fibroids using new MRI techniques.

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Abstract:Uterine fibroids are the most common gynaecological tumors affecting a high percentage of women. MR-HIFU is a new treatment technique, combining the anatomical and functional imaging of MRI with the thermal ablation possibilities of high intensity focused ultrasound. Patient selection, based on screening MRIs, before MR-HIFU treatment is an essential step towards obtaining good treatment results. We hypothesize that visualizing fibroid characteristics with new MRI sequences and image biomarkers contributes to a better patient selection and therefore better treatment results. The goal of this study is to implement a novel and extensive MRI protocol in the diagnosis of uterine fibroids in the current practice of the Isala Clinics. We implemented a novel MRI protocol, including T2 relaxometry and diffusion weighted imaging. We performed the MRI scans on 10 patients. All 10 patients completed the symptom severity questionnaire. The mean symptom severity score was 37.1 ± 20.3. T2 relaxometry maps and ADC maps measurements can be performed in all patients. The functional imaging parameters show a difference between normal myometrium and uterine fibroid. Because a variety is seen in fibroid volume, symptom severity score and the values of the different imaging parameters among patients underline our hypothesis: we find a wide variety and heterogeneity among patients suffering from uterine fibroids.
Item Type:Essay (Master)
Clients:
Isala, Zwolle, Netherlands
Faculty:TNW: Science and Technology
Subject:44 medicine
Programme:Technical Medicine MSc (60033)
Link to this item:http://purl.utwente.nl/essays/69405
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