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Microwave ablation of solitary breast cancer for elderly women & Neurostimulation of the celiac plexus as a treatment for overweight and obesity : an exploration of the steps needed for a clinical study

Samarrai, Dhabia al (2016) Microwave ablation of solitary breast cancer for elderly women & Neurostimulation of the celiac plexus as a treatment for overweight and obesity : an exploration of the steps needed for a clinical study.

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Abstract:Breast cancer is the most common type of cancer in women. Based on current incidence rates, the chance is one in eight for Dutch women to develop breast cancer at some time during their lives. Current standard of care treatments for breast cancer include: surgery, radiation therapy, chemotherapy and hormonal therapy depending on the stage of the cancer at clinical presentation. Breast surgery can involve either breast conservation therapy, which can be performed as a lumpectomy, or it can involve a mastectomy. Recent studies show no difference in the overall survival between lumpectomy and mastectomy. Since this discovery, there is a growing tendency to use minimal invasive approaches for the local treatment of tumours. MWA is an interesting recent minimal invasive technique for the treatment of breast cancer. MWA has selective properties for breast tissue. The dielectric properties, conductivity and permittivity, in malignant tissue is higher than in the host tissue which contains fatty and glandular tissue. Surgery is the golden standard, however, there is a group of patients who is not eligible for conventional therapy. Elderly women with a solitary, small breast tumour could be treated successfully with percutaneous MWA. The focus of this study is on the following research questions: 1. What is the technical efficacy of MWA for solitary, small primary breast tumours in an ex vivo setting? 2. How accurate and predictable is the target zone created during MWA? To the best of our knowledge, is this the first study where the Emprint ablation system is used to treat breast cancer. Small breast cancer, less than 1.5 cm in diameter are included in the study. Our purpose is to perform ten valid MWA measurements in breast specimen resectioned from women who had surgery. MWA was conducted on bovine liver and one resection specimen to determine the appropriate settings of the system. Generator settings of 100 Watt for the duration of at least 3 minutes are expected to be effective for the next specimen, dependent on the tumour size and the margin. This work discusses the results, the potential application of MWA as a local treatment for breast cancer and the preconditions for clinical implementation.
Item Type:Essay (Master)
Clients:
JEROEN BOSCH HOSPITAL, DEN BOSCH, NL
Faculty:TNW: Science and Technology
Subject:44 medicine
Programme:Technical Medicine MSc (60033)
Link to this item:http://purl.utwente.nl/essays/70320
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