University of Twente Student Theses


Quantification of ASL and DTI Data in the Brain of Patients with Alzheimer’s Disease

Oever, L.B. van den (2016) Quantification of ASL and DTI Data in the Brain of Patients with Alzheimer’s Disease.

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Abstract:This master thesis describes a part of a large research project that investigates a new treatment for Alzheimer’s disease (AD). During this project, magnetic resonance images (MRI) of the brain were made in patients with AD. With the data from this research, we investigated the pathophysiology of AD. AD is a neurodegenerative disorder that manifests itself in memory loss, location and time mismatches, mood swings and changes in personality and behaviour. The cause of AD is largely unknown. Changes in perfusion are present in AD and thought to have an effect on the functioning of the brain. It is unknown where these perfusion changes originate, what causes them and what effect hypoperfusion has on the brain tissue itself. Although we will discuss this further in chapter 2 of this thesis, we want to investigate the effect of perfusion of brain regions on the white matter tracts in the brain. Perfusion can be measured with a magnetic resonance imaging (MRI) sequence called arterial spin labelling (ASL), while white matter integrity can be measured with diffusion tensor imaging (DTI). There are many different ways to analyse MR data. All of them have to be adapted for use in specific modalities and patient groups, so we will have to develop a processing pipeline to quantify both ASL data and DTI data.
Item Type:Essay (Master)
Faculty:TNW: Science and Technology
Subject:50 technical science in general
Programme:Technical Medicine MSc (60033)
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