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Preferences of women in deciding about treatment by low-grade DCIS : a hypothetical preference study

Geerts, C.W.G. (2016) Preferences of women in deciding about treatment by low-grade DCIS : a hypothetical preference study.

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Abstract:Ductal Carcinoma In Situ (DCIS) is a precursor of invasive breast carcinoma. If untreated, it is estimated that 10-15% of low-grade DCIS will develop into invasive breast carcinoma. Because there is little evidence about the prognosis of DCIS, in most cases women detected with DCIS will be treated as if it is invasive breast carcinoma; mastectomy or lumpectomy and radiotherapy. Knowing that a substantial number of DCIS lesions will never form a health hazard, most women with low-grade DCIS might be over treated. Currently, a European randomized inferiority trial (LORD) is set up to test if screen-detected low-grade DCIS can be safely managed by an active surveillance (AS) strategy only. Because future patients may be confronted with this decision option, we studied the preferences of women about low-grade DCIS treatment using a Discrete Choice Experiment (DCE). Based on the results, the level of disfigurement due to choice of intervention was the most important attribute for choice of low-grade DCIS treatment. Understanding the preferences of women in the general population may help to enhance the informed decision-making process based on the needs of patients.
Item Type:Essay (Master)
Faculty:TNW: Science and Technology
Subject:44 medicine
Programme:Health Sciences MSc (66851)
Link to this item:http://purl.utwente.nl/essays/70830
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