University of Twente Student Theses


Quantification of amyloid-PET scans in early detection of Alzheimer’s disease

Tenbergen, C.J.A. (2017) Quantification of amyloid-PET scans in early detection of Alzheimer’s disease.

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Abstract:Amyloid imaging by using 18F-florbetapir PET scans has increased the knowledge on amyloid plaques in relation to Alzheimer’s disease. Besides the diagnostic value, these scans can have a potential therapeutic relevance. The amyloid PET scans should be assessed by a method that can provide quantitative feedback about the intervention, can measure change in amyloid burden and highlight mild effects overlooked by visual comparison. By combining information from both amyloid PET scans and individual MRI scans of 108 patients from the ADNI database, specific grey matter amyloid burden was measured. With the use of a white matter reference region, results can be compared between patients. By linking the amyloid measurements to the subject’s diagnosis known in ADNI, a model was created giving a prediction of the prospects of MCI patients. The main finding of this research is that the developed method can discriminate MCI patients that will convert to AD from MCI patients who will not. The created model showed high predictive power in subjects converting from MCI to either AD or HC. The developed workflow facilitates early diagnosis which yields eligible patients for drug treatment and is a start of a tool for accurately quantifying and tracking of treatment effects.
Item Type:Essay (Bachelor)
Faculty:TNW: Science and Technology
Subject:42 biology, 44 medicine, 50 technical science in general
Programme:Technical Medicine BSc (50033)
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