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On-Chip HPLC analysis of drugs of abuse - Analysis of cocaine, morphine and their metabolites using an on-chip HPLC system.

Hilgerink, T. (2016) On-Chip HPLC analysis of drugs of abuse - Analysis of cocaine, morphine and their metabolites using an on-chip HPLC system.

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Abstract:Being able to analyse drugs of abuse in blood at a crime scene can save a lot of time and money. Lab-on-a-chip devices could possibly be used to achieve this goal. A microchip based HPLC system coupled to UV-Vis has been used to developed a method for simultaneous measurements of cocaine, benzoylecgonine, morphine and morphine-3ß-D-glucorinide in water. Methods to prepare blood for on-chip analyses are also discussed in this thesis. The research showed concentrations of 12.5 mg/L could be measured, with a high possibility of being able to measure much lower concentrations as well.
Item Type:Essay (Master)
Faculty:TNW: Science and Technology
Subject:35 chemistry
Programme:Science Education and Communication MSc (68404)
Link to this item:http://purl.utwente.nl/essays/71895
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