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CircAdapt: Model validation and prediction of anatomical and haemodynamic parameters for patients with mitral insufficiency

Kleinveld, E. and Hulst, E. van and Pham, S. D. T. (2017) CircAdapt: Model validation and prediction of anatomical and haemodynamic parameters for patients with mitral insufficiency.

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Abstract:Introduction: It is still unclear which of the many treatment options for a mitral insufficiency (MI) would give the best result for each individual patient. Patient specific simulations in haemodynamic circulation models could be the solution. The aim of this study is to take a step towards the validation of the CircAdapt model and to gain knowledge about the different aspects that could play a role in MI. Method: Simulations of the heart and circulatory dynamics in patients with MI are done with the Circ- Adapt mathematical model. Validation of CircAdapt with exercise capacity and left ventricular ejection fraction (LVEF) was done with patient data from Maastricht University Medical Centre (MUMC). The influence of the effective regurgitant orifice area (EROA), effective orifice area (EOA) and cavity dilatation on the exercise capacity of MI patients was examined. Also, the effect of the MitraClip was simulated. Results: The data regarding exercise capacity cannot be used to validate CircAdapt. The simulated LVEF resembles the trend in the patient data. Out of all the cavities, right ventricular (RV) function has the greatest influence on the exercise capacity of MI patients. EOA has a bigger influence on the exercise capacity for smaller EROAs. Conclusion: For further validation studies and patient specific simulations, the measurement and handling of the necessary data has to be improved. CircAdapt cannot be validated with restricted patient data. The simulation results are in line with the expectations based on known physiology and pathology. Furthermore, a prospective study with a homogeneous population should be considered. It is interesting to examine the function and mechanics of the RV further. Relationships between single input parameters need to be further researched and adopted into CircAdapt for a better representation of reality.
Item Type:Essay (Bachelor)
Faculty:TNW: Science and Technology
Subject:42 biology, 44 medicine
Programme:Technical Medicine BSc (50033)
Link to this item:http://purl.utwente.nl/essays/72549
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