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Measurement of the hypercapnic ventilatory response : development and clinical application

Boele, D.C. (2017) Measurement of the hypercapnic ventilatory response : development and clinical application.

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Abstract:Introduction: The relationship between PCO2 and the resulting minute ventilation is known as the hypercapnic ventilatory response (HCVR). Two types of methods are available to measure the HCVR: rebreathing and steady-state method. The aim of this study is to investigate which method is best suitable for use in clinical practice. The key factor is the reproducibility of slope of the HCVR. Methods: Twenty healthy adults were enrolled in the study. On two visits (5-9 days apart) the hyperoxic HCVR was measured with a rebreathing and steady-state method, in random order. The intra-class coefficient (ICC) of the slopes of the HCVR were used to assess the reproducibility. Results: The ICC (95% confidence interval) of the rebreathing method was 0.89 (0.73-0.95), and 0.56 (0.14-0.81) for the steady-state method. The ICC of the short slope in the rebreathing method was 0.78 (0.51-0.91). Discussion: The rebreathing measurements are reproducible, the steady-state measurements are not. The variability of PCO2 is a key factor in the poor reproducibility of the steady-state measurements. Variations in method can influence the measured slope, which affects clinical conclusions. Conclusion: Based on the reproducibility of the measurements, it is preferred to use the rebreathing method to measure the hypercapnic ventilatory response.
Item Type:Essay (Master)
Faculty:TNW: Science and Technology
Subject:44 medicine
Programme:Technical Medicine MSc (60033)
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