University of Twente Student Theses


Local pulse wave velocity as a cardiovascular biomarker

Lochem, P van (2018) Local pulse wave velocity as a cardiovascular biomarker.

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Abstract:Increased arterial stiffness in the cardiovascular (CV) system is associated with CV diseases and events. Due to lack of reliable methods, however, conventional arterial stiffness methods have not resulted in widespread application in the current clinical setting. Therefore, a new method is developed to measure the local pulse wave velocity by plane wave ultrasound imaging. The local pulse wave velocity can be measured accurately at the systolic foot (LPWVSF) and the dicrotic notch (LPWVDN) by using the radial acceleration values of the common carotid artery wall. The reproducibility of both velocity methods is determined using multiple measurements obtained from young healthy volunteers (n=12) and CV patients (n=19) with similar blood pressures and heart rates, but with significant differences in other CV risk factors. A significantly higher pulse wave velocity is found in the CV patient group in comparison with the healthy volunteer group (LPWVDN: 7.1 ± 1.4 m/s versus 5.4 ± 1.3 m/s, p < 0.001). The LPWVDN method appears to outperform the LPWVSF method, demonstrating more stable performance within this study population. However, the reproducibility within subjects with both methods is rather low, with an average coefficient of variation of approximately 20%. Consequently, the reproducibility first needs to be improved before the predictive value of the LPWVDN method can be investigated as a biomarker for CV diseases.
Item Type:Essay (Master)
Faculty:TNW: Science and Technology
Subject:44 medicine
Programme:Technical Medicine MSc (60033)
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