University of Twente Student Theses


Feasibility of irreversible electroporation for pulmonary vein isolation

Groen, M.H.A. (2018) Feasibility of irreversible electroporation for pulmonary vein isolation.

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Abstract:Pulmonary vein isolation (PVI) can be used as treatment for atrial fibrillation. Radio frequency (RF) ablation is the common used method to perform a PVI. However, success rate remains limited and several complications might occur due to excessive heating of tissue and blood. Therefore, irreversible electroporation (IRE) was investigated as an alternative ablation modality. Previous studies demonstrated the feasibility of using a circular catheter for performing PVI using IRE, the possibility of creating a continuous lesion depth of >4mm and the absence of complications associated with RF ablation as for example nerve injury, PV stenosis and damage to arteries. In the present study we have investigated the differences between anodal and cathodal IRE ablations with respect to gas formation, joule heating and the occurrence of arcing during IRE-ablations, both in vitro and in vivo. Overall results of this thesis indicate that anodal IRE-pulses should be preferred over cathodal IRE-pulses. IRE-ablation using anodal IRE-pulses is a promising ablation modality as replacement of RF-ablation to perform PVI.
Item Type:Essay (Master)
University Medical Center Utrecht, Utrecht, Nederland
Faculty:TNW: Science and Technology
Subject:44 medicine, 50 technical science in general
Programme:Technical Medicine MSc (60033)
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