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Late, treatment-induced cardiac morbidity after breast-conserving surgery in breast cancer patients

Storck, Chantal (2018) Late, treatment-induced cardiac morbidity after breast-conserving surgery in breast cancer patients.

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Abstract:Background: Breast cancer patients treated with radiotherapy (RT) and/or adjuvant systemic therapy may have a higher risk of cardiovascular diseases (CVDs) due to cardiac toxicity years after their oncological treatment. Results: In the 62 patients treated with BCS, RT and adjuvant systemic therapy in total 62 cardiac events were observed in 19 patients, and 54 cardiac events were observed in 21 patients treated with BSC and RT (n=61). No significant differences in the total number of cardiac events, development of a major adverse cardiac event (MACE), or cardiac events separately between the two treatment groups could be revealed. Moreover, no significant differences in DFS and OS were observed between the two treatment groups up to 28 years after BCS (DFS p=0.756; OS p=0.437). Conclusion: There is no difference in the development of cardiac morbidity and the need for cardiovascular interventions between women treated with BCS followed by RT and adjuvant systemic therapy, and women treated with BCS followed by RT only. Next to that, laterality was not shown as a significant risk factor for the development of CVDs in patients treated with BCS followed by RT with or without adjuvant systemic therapy.
Item Type:Essay (Master)
Faculty:TNW: Science and Technology
Subject:44 medicine
Programme:Health Sciences MSc (66851)
Link to this item:http://purl.utwente.nl/essays/75315
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