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Late general and neurological effects after breast conserving surgery and radiation therapy with or without systemic therapy in breast-cancer survivors

Zinkweg, R.A. (2018) Late general and neurological effects after breast conserving surgery and radiation therapy with or without systemic therapy in breast-cancer survivors.

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Abstract:The leading type of cancer within women in the Netherlands is breast cancer. Out of all women in the Netherlands diagnosed with cancer in 2017, 28% is diagnosed with breast cancer. Current breast cancer treatments can consist of surgery, radiation therapy with or without systemic therapy. Late effects analyzed in this study are general and neurological effects after breast cancer treatments. In total 49 patients from cohort 1 developed one or more general late effects (80.3%) and 12 patients developed one or more neurological late effects (19.7%). In cohort 2, 52 patients developed one or more general late effects (83.9%) and 15 patients developed one or more neurological late effects (24.6%). Fewer second primary tumors were found in cohort 2, which is related to the given treatment to those patients, namely systemic therapy. Next to that, an expedited menopause only occurred in premenopausal women who received adjuvant chemotherapy. No differences were found in neurological late effects between the cohorts. Furthermore, no other significant differences were found in late effects between the two cohorts. Next to that, in overall survival and disease-free survival (all late general or neurological effects) no significant difference was found between the two cohorts.
Item Type:Essay (Master)
Clients:
Unknown organization, Netherlands
Faculty:TNW: Science and Technology
Subject:44 medicine
Programme:Health Sciences MSc (66851)
Link to this item:http://purl.utwente.nl/essays/75316
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