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Development of a human peripheral myelinated axon model

Durmus, N. (2018) Development of a human peripheral myelinated axon model.

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Abstract:We developed a mathematical model of the human peripheral myelinated motor and sensory axon, which incorporates nodes of Ranvier and detailed internodal regions including the paranode, juxtaparanode and standard internode with the myelin modelled using a double-cable structure, with a fiber diameter of 10.0 µm at 36 oC. To accurately simulate the human peripheral myelinated axon, we modified the parameters for the nodal and internodal membrane dynamics to those found in patch-clamp studies and used in human peripheral nerve excitability testing. The sensory axon was simulated with respect to the motor axon by a decreased slow potassium channel conductance, an increased internodal inward rectifier current, a depolarizing shift of the voltage for half-activation for HCN channels and depolarization of the resting membrane potential. The developed model consists of detailed morphological and biophysical properties of the human peripheral myelinated motor and sensory axon. These computational platforms make it possible to systematically study downstream mechanisms of peripheral nerve diseases, which cannot be assessed with experimental studies. Obtaining insight into these mechanisms is essential, because it may provide knowledge on what morphological or functional elements are most likely targeted, which aids the development of novel treatment strategies to prevent irreversible nerve damage.
Item Type:Essay (Master)
Faculty:TNW: Science and Technology
Subject:44 medicine, 50 technical science in general
Programme:Technical Medicine MSc (60033)
Link to this item:http://purl.utwente.nl/essays/76582
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