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Improving post-treatment dosimetry for selective intra-arterial radiation therapy in liver metastases

Kronenberg, Bsc. A.A. (2018) Improving post-treatment dosimetry for selective intra-arterial radiation therapy in liver metastases.

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Abstract:Radioembolisation is an internal radiation therapy in which 90Y–loaded microspheres are delivered transarterially to hepatic malignancies. Within one day after therapy, 90Y-PET is performed to visually assess whether the 90Y microspheres have reached the tumor(s). The first objective of this study was to assess the quantitative accuracy of two PET/CT scanners for the purpose of quantification absorbed doses of 90Y microspheres after radioembolisation. Two experiments were performed with means of a phantom containing six fillable spheres of different diameters and a background compartment. All results confirm the limited quality of the 90Y-PET scan for quantification purposes. The results indicate that only lesions larger than 11.49cm3 and receive an activity concentration higher than 70kBq/ml can be used for quantification. The second objective was to determine prognostic factors for treatment response by performing post-treatment dosimetry on 90Y-PET/CT scans of 33 lesions treated with radioembolisation. Target lesions received an average dose of 61Gy. Progression was observed in 17 of the 33 target lesions. Only target lesion volume was found to be significantly associated with response to treatment. In the future, thought can be given to the use of positron emitter labelled 90Y microspheres, thereby boosting the positron emitted signal of 90Y microspheres.
Item Type:Essay (Master)
Faculty:TNW: Science and Technology
Subject:44 medicine, 50 technical science in general
Programme:Technical Medicine MSc (60033)
Link to this item:http://purl.utwente.nl/essays/76607
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