University of Twente Student Theses
A comparison between iDose4 and IMR on the amount of blooming in a CT-Angiogram of patients suffering from peripheral arterial disease in the aortoiliac tract
Baltus, S.C. and Kar, N.E. van de and Spijkerboer, K.G.P. and Teule, E.H.S. (2019) A comparison between iDose4 and IMR on the amount of blooming in a CT-Angiogram of patients suffering from peripheral arterial disease in the aortoiliac tract.
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| Abstract: | Objectives: When diagnosing PAD with CTA blooming artefacts may influence the accuracy of analysing the percentage lumen loss. This study compares different IMR settings to the iDose4 reconstruction to analyse the amount of blooming visible in CTA images. The aim of this study was to determine the optimal setting of the reconstruction techniques for imaging PAD with minimal blooming. Method: Three parameters were used to determine the amount of blooming present in CTA images: the percentage area and diameter of the stenosis and the maximum gradient of the intensity value over the transition lumen - stenosis. All parameters were calculated with a semi-automatic MATLAB algorithm using segmentation techniques. For this study, a vascular phantom was designed and created. This phantom contained three artificial vessels with four known degrees of stenoses and was used to compare the different settings of the reconstruction techniques. The results were compared to the ground truth (GT) of the phantom dimensions to determine which setting could minimise blooming of the stenosis best. The findings of the phantom data could be complemented by the evaluation of patient data (n=5) that was analysed on the same parameters. Results: All area and diameter measurements of the phantom data show an underestimation of the stenosis compared to the GT. For the percentage area of the stenosis, SP1 measures significantly closest to the GT (-7.61%, ±4.65) compared to the iDose4 reconstruction. For the percentage diameter of the stenosis, R1 measures most accurately to the GT (-8.62%, ±5.19) compared to the iDose4 reconstruction, however, this difference is not significant. Results of the paired t-test show that the iDose4 reconstruction measures significantly more accurate than all SharpPlus settings. For the parameter intensity value SP3 has the highest mean (0.270, ±0.031) and is significantly different compared to the iDose4 reconstruction. No statistical analysis has been conducted on the patient data. The area and diameter measurements show different results for the reconstruction technique showing the highest percentage stenosis. The intensity value parameter shows that SP2 has the highest mean value whereas iDose4 has the lowest mean value. Conclusion: Contradicting to the hypothesis, the results of this study show that the area and diameter parameters underestimate the stenosis compared to the GT. This makes it difficult to conclude to what extent blooming is present in the different reconstruction techniques. Therefore, the conclusion is based on the parameter intensity value. This parameter shows that SharpPlus L3 has the highest maximum gradient and thus the clearest boundary between lumen and stenosis. This indirectly indicates that SharpPlus L3 minimises blooming best, whereas iDose4 scores the lowest maximum gradient and therefore shows the most amount of blooming. Keywords: Blooming, IMR, iDose4, Stenosis, Computed Tomography Angiography, Peripheral Arterial Disease |
| Item Type: | Essay (Bachelor) |
| Clients: | Rijnstate hospital, Arnhem, The Netherlands |
| Faculty: | TNW: Science and Technology |
| Subject: | 44 medicine, 50 technical science in general |
| Programme: | Technical Medicine BSc (50033) |
| Link to this item: | https://purl.utwente.nl/essays/77159 |
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