University of Twente Student Theses


Non-invasive electrocardiographic imaging in patient with idiopathic ventricular fibrillation

Wulterkens, Bernice (2019) Non-invasive electrocardiographic imaging in patient with idiopathic ventricular fibrillation.

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Abstract:The purpose of this study was to develop a method for (semi-)automatic calculation of repolarization parameters in unipolar electrograms reconstructed with ECGI. Repolarization parameters include Tpeak-Tend (Tp-e) interval, T-wave area, T-wave amplitude and T-wave alternans. The algorithm was validated against two observers and achieved a maximum sensitivity of 93.5% and 27.5% for the (primary) T-peak and T-end respectively. The algorithm was applied on ECGI-data of five patients with IVF and one control subject. We showed that it is possible to visualize epicardial repolarization parameters using ECGI. The results suggest that Tp-e intervals and T-wave alternans measured with ECGI can provide information about the substrate for the development of VF in IVF and provides a foundation for further exploration of the repolarization characteristic in a larger study population and in control subjects. Furthermore, the presence of late gadolinium enhancement (LGE) on cardiac magnetic resonance (CMR) imaging has been visualized using the software program CARTBox. The results indicate the diversity in the location and the extent of transmurality of LGE between the subjects. The obtained 3D reconstructions enable comparison of LGE regions with 3D images obtained by ECGI.
Item Type:Essay (Master)
Faculty:TNW: Science and Technology
Subject:44 medicine
Programme:Technical Medicine MSc (60033)
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