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High-frame-rate contrast-enhanced ultrasound particle image velocimetry near the stented superficial femoral artery : A feasibility study

Helvert, Majorie van (2019) High-frame-rate contrast-enhanced ultrasound particle image velocimetry near the stented superficial femoral artery : A feasibility study.

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Abstract:Purpose - Analysis of local blood flow patterns near stenotic lesions in the femoral trajectory may provide insight in progression of disease and improve its diagnosis and treatment. High-frame-rate contrast-enhanced ultrasound, or echo PIV, seems a promising technique in visualizing and quantifying local flow profiles. This thesis discusses the first assessment of clinical feasibility of echo PIV in patients recently treated with a stent in the superficial femoral artery (SFA) (2). Method - Clinical echo PIV measurements were performed at five different locations near the femoral bifurcation and the stented SFA in a pilot of twenty patients. Vessel visibility and contrast-to-background ratio (CBR) were evaluated as a measure of image quality. Accuracy of PIV was analyzed using the maximum normalized cross-correlation value and peak systolic velocity compared to duplex US. Results - Echo PIV data of twelve patients was successfully acquired. Quality of the measurements showed varying results in terms of vessel visibility and CBR between and within patients. Data of one patient was further analyzed through PIV. In two out of five locations adequate PIV results were found, showing high cross-correlation values and a velocity difference within 10% compared to duplex US. Conclusion - First assessment of echo PIV showed varying results which seem linked to the quality of the obtained data. Accurate blood flow velocity tracking was established in data with high CBR values. More data should be analyzed and improvements in PIV methods should be explored in order to draw a thorough conclusion regarding feasibility of echo PIV in quantifying blood flow in the femoral bifurcation and the stented SFA.
Item Type:Essay (Master)
Faculty:TNW: Science and Technology
Subject:33 physics, 44 medicine
Programme:Technical Medicine MSc (60033)
Link to this item:http://purl.utwente.nl/essays/78637
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